Last Updated:
April 30, 2024
How the SARS-CoV-2 viral protein damages the heart
Researchers at the Center for Precision Disease Modeling at the University of Maryland School of Medicine (UMSOM) determined how a specific protein in the SARS-CoV-2 virus that causes COVID-19 damages heart tissue. They then used a drug to reverse the toxic effects of the protein on the heart. Their finding was based on studies of Drosophila and mouse heart cells, and was published in Communications Biology. Compared to virus-uninfected people, people infected with COVID-19 have a significantly higher risk of developing myocardial inflammation, abnormal heart rhythm, blood clots, stroke, heart attack, and heart failure at least one year after infection. Although scientists have rapidly developed vaccines and drugs to reduce the severity of COVID-19 disease, these therapies do not protect the heart or other organs from damage that may be caused by even minor infections. “To treat patients for a long time, we must first understand the mechanisms that lead to disease. Our study suggests that individual SARS-CoV-2 proteins can cause significant damage to specific tissues of the body, similar to findings for other viruses such as HIV and Zika virus,” said Dr. Zhe Han, senior author, professor of medicine, and director of the Center for Precision […] read more
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Choosing the Proper Virus PCR Kit: Factors to Consider
Within the subject of virology and diagnostic testing, Polymerase Chain Response (PCR) has revolutionized the detection and identification of viruses. PCR is a sensitive and accurate method that amplifies particular DNA or RNA sequences, allowing for the detection and quantification of viral genetic material. Nevertheless, to ensure reliable and accurate outcomes, it is essential to decide on the correct virus PCR kit. This article will talk about the key factors to consider when selecting a virus PCR kit. Goal Virus: The primary and most important consideration is the goal virus. Completely different PCR kits are designed to detect specific viruses or teams of viruses. Therefore, it is essential to establish the goal virus or viruses you need to detect. Consider the prevalence and significance of the virus in your area or research field. Make sure the PCR kit you choose has primers and probes particular to your target virus. Sensitivity and Particularity: Sensitivity and specificity are critical parameters that determine the accuracy and reliability of a PCR kit. Sensitivity refers back to the kit’s ability to detect low levels of the target virus, while specificity refers to its ability to distinguish the goal virus from intently associated viruses or non-target […] read more
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